Your biggest problem seems to be a very high roll wait time. That is usually cause by having too few dialog work processes. Run SM50 and look at the values in the CPU column for the dialog processes. I'm guessing they will all be quite high. A simple way to check if you have enough dialog wps is that in SM50 one of them should have zero, or near zero, CPU time. If that's not true for you, add some more.
The hit ratio for most of your buffers is pretty high despite the buffer swaps. There will always be some. Whether those numbers are high or not depends on how long the system has been running - you didn't include that in the ST02 screen shot so we can't tell. There's one obviously low one, but otherwise I wouldn't worry too much about them. Address the roll wait time first.
Steve.